Why Is Low Blood Cholesterol

Associated with Increased Late Life Mortality?

Story at-a-glance

• Low cholesterol levels are associated with increased mortality risk in older adults, challenging the "lower is better" paradigm
• Cholesterol plays crucial roles in cell membrane structure, hormone production, vitamin D synthesis and nerve function. Adequate levels are essential for optimal health, especially in older individuals
• Low cholesterol is linked to higher diabetes risk in older adults. Both very low and very high levels increase risk, with the lowest risk occurring at moderate levels
• Maintaining adequate cholesterol levels is important for brain health, particularly in post-menopausal women. Low levels may disrupt lipid rafts and myelin production, potentially affecting cognitive function
• Recent research indicates a relationship between low cholesterol and increased risk of blood cancers. Cholesterol has protective effects on immune function and regulation of cancer cell proliferation

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